منابع مشابه
Knockin' on the door of general anesthetic mechanisms: but will U.S. researchers be shut out?
I n the last 3 years, we have witnessed exciting new developments in our understanding of anesthetic mechanisms. This editorial comments on the review by Sonner et al. (1) and describes recent key advances in the field. In a recent commentary I drew attention to the growing perception of the importance of ion channels, especially -aminobutyric acid (GABA)-A and N-methyl-daspartic acid (NMDA) re...
متن کاملInfantile spasms.
Infantile spasms constitute both a distinctive seizure type and an age-specific epilepsy syndrome that have been extensively described for over a century. Standardization of the classification of infantile spasms has evolved, culminating in recent recommendations for separately recognizing and distinguishing the seizure type (spasms or epileptic spasms) and the epilepsy syndrome of infantile sp...
متن کاملInfantile spasms.
Overview Infantile spasms, also known as West syndrome, is a catastrophic childhood epilepsy with seizures that are difficult to control; it is associated with mental retardation. It usually has an onset during the first year of life, and typically between 4 and 8 months. Early recognition, careful diagnostic evaluation, and proper treatment may allow some children to attain seizure control and...
متن کاملThe latest on infantile spasms.
PURPOSE OF REVIEW This article reviews the most significant advances in the field of infantile spasm during the past year, with emphasis on best practise for treatment, and on some new etiological genetic and metabolic causes for the spasms, and new advances in the knowledge of tuberous sclerosis. RECENT FINDINGS Up-to-date information comparing corticotrophin, oral steroids and vigabatrin sh...
متن کاملAPC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures
Infantile spasms (IS) are a catastrophic childhood epilepsy syndrome characterized by flexion-extension spasms during infancy that progress to chronic seizures and cognitive deficits in later life. The molecular causes of IS are poorly defined. Genetic screens of individuals with IS have identified multiple risk genes, several of which are predicted to alter β-catenin pathways. However, evidenc...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2017
ISSN: 1535-7597,1535-7511
DOI: 10.5698/1535-7511.17.3.177